NMN Supplements Are Back: What You Need To Know

Key Takeaways

• The FDA Update: Following a period of market uncertainty, NMN is once again being sold by major supplement retailers in the U.S.
• Is NMN Available for Purchase?: Yes, NMN is currently available for purchase from reputable supplement retailers in the United States.
• Why It's a Big Deal: NMN is a science-backed precursor to NAD+, a vital coenzyme for cellular energy and DNA repair that declines with age.
• Where to Buy Safely: It's crucial to purchase from trusted retailers offering third-party tested products, such as California Gold Nutrition's NMN, available at iHerb.

NMN Supplements Are Back

After a period of regulatory uncertainty, NMN supplements are once again widely available on the market. If you've been wondering about the latest NMN FDA update or where you can safely buy NMN, you're in the right place. 

By boosting NAD+, supplementation with NMN supports cellular metabolism, healthy aging, brain function, and physical performance and recovery. With NMN, you can fuel your cells, fuel your future, and promote healthy aging starting at the cellular level.

This guide explains the current status of NMN and why it remains a top supplement for healthy aging.

Where To Buy High-Quality NMN

What To Look For In An NMN Supplement

• Purity and Form: Choose β-Nicotinamide Mononucleotide, the form used in most clinical studies. 
• Third-Party Testing: Look for products tested by independent labs to confirm potency and purity.
• Manufacturing Standards: Choose supplements produced in cGMP-certified facilities to help ensure consistency and safety.

California Gold Nutrition’s NMN

Product Spotlight: California Gold Nutrition’s NMN provides β-Nicotinamide Mononucleotide in a clean formula, free of gluten, GMOs, and soy, and is manufactured in a third-party audited cGMP facility. Each capsule provides 175 mg, making it easy to adjust intake based on personal needs.

California Gold Nutrition’s NMN is available exclusively at iHerb—providing premium quality without the price tag. If you’re interested in trying NMN, look for a high-quality, third-party tested product such as California Gold Nutrition’s NMN and give your cells the energy they need to thrive as you age.

5 Benefits Of NMN Supplements

1. Supports Cellular Health + Healthy Aging

NMN increases NAD+ levels, which in turn activate sirtuins, often called longevity factors. Sirtuins are proteins that regulate cellular repair, stress resistance, and metabolic balance. Research also suggests that NMN supplementation supports cellular health and resilience against age-related stressors.^1,2

2. Supports Cellular Energy + Metabolism

NAD+ is fundamental for mitochondrial energy production—the conversion of food into usable cellular energy (ATP). By supporting healthy NAD+ levels, NMN supplements may help reduce fatigue, improve physical performance, and enhance overall vitality. Some human clinical trials report improved physical functions, walking distance, and energy scores after NMN use.^3-5

3. Enhances Insulin Sensitivity + Metabolic Health

Several human clinical studies have found that NMN supplementation supports insulin sensitivity in healthy adults. This emerging clinical data suggests a promising role for NMN in supporting healthy metabolic function as you age.^6,7

4. Supports Brain Health + Cognitive Function

The brain consumes enormous amounts of energy, and NAD+ is critical for keeping neurons healthy. Preliminary research indicates NMN supplementation may support cognitive function and brain health as part of healthy aging. While human trials are ongoing, the early data are encouraging.^1,2

5. Promotes Heart + Vascular Health

Healthy blood vessels are crucial for cardiovascular function. NAD+ supports endothelial cells, which line the blood vessels, helping maintain flexibility and blood flow. Emerging preclinical research suggests NMN supports factors associated with healthy vascular function.^1,2

What Is NMN + Why Is It A Hot Topic In Anti-Aging?

The quest to slow aging and maintain youthful energy has fascinated scientists and health seekers alike. One molecule at the center of this research is NMN, often described as a “cellular fuel booster.”

NMN is a compound that is naturally produced in the body and found in trace amounts in certain foods. Its primary role is to serve as a precursor to NAD+ (Nicotinamide Adenine Dinucleotide), a coenzyme essential for energy production, DNA repair, and the activity of longevity-associated enzymes called sirtuins.^1,2

The challenge? NAD+ levels decline sharply with age, by about half by the time we reach middle age. This drop is linked with fatigue, slower metabolism, and diminished cellular resilience.

Dosage And Best Practices

NMN has been well-tolerated in human clinical studies at doses ranging from 250 mg to 1,250 mg daily. Consult with your healthcare provider before use, especially if you are taking medication.

NMN is best taken in the morning on an empty stomach and again in the evening an hour or so before bedtime. 

Common Questions About NMN

Is NMN banned by the FDA?

No. While the FDA previously raised questions about NMN's regulatory status, it is currently being sold openly in the U.S. supplement market without enforcement action.⁸

Is it safe to buy NMN online?

Yes, provided you buy from a trusted retailer that offers third-party tested products from cGMP-certified facilities, like iHerb.

What’s the difference between NMN and NR (Nicotinamide Riboside)?

Both NMN and NR are NAD+ precursors. NR must first convert into NMN before becoming NAD+, so NMN may be a more direct pathway. 

How long does it take for an NMN supplement to work?

In most studies, increases in blood NAD+ levels are seen within 2–4 weeks. Improvements in energy and metabolic health may take longer and vary by individual.

Are there any side effects of taking NMN?

NMN has been well-tolerated in human trials at doses up to 1,250 mg per day. Some users report mild digestive upset if taken on an empty stomach.

Can I get enough NMN from food?

Foods like broccoli, cucumbers, avocados, and edamame contain trace amounts of NMN. It would be difficult to provide the same clinically verified dosages from these foods. 

References:

1. Wang M, Cao Y, Li Y, et al. Research advances in the function and anti-aging effects of nicotinamide mononucleotide. J Zhejiang Univ Sci B. 2024 Sep 15;25(9):723-735.
2. Bonkowski MS, Sinclair DA. Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds. Nat Rev Mol Cell Biol. 2016 Nov;17(11):679-690. 
3. Irie J, Inagaki E, Fujita M, et al. Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men. Endocr J. 2020;67(2):153-160.
4. Liao B, Zhao Y, Wang D, et al. Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: A randomized, double-blind study. J Int Soc Sports Nutr. 2021;18(1):54.
5. Morifuji M, Higashi S, Ebihara S, Nagata M. Ingestion of β-nicotinamide mononucleotide increased blood NAD levels, maintained walking speed, and improved sleep quality in older adults in a double-blind randomized, placebo-controlled study. Geroscience. 2024 Oct;46(5):4671-4688.
6. Yoshino M, Yoshino J, Kayser BD, et al. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. 2021;372(6547):1224-1229. 
7. Chen F, Zhou D, Kong AP, et al. Effects of Nicotinamide Mononucleotide on Glucose and Lipid Metabolism in Adults: A Systematic Review and Meta-analysis of Randomised Controlled Trials. Curr Diab Rep. 2024;12;25(1):4.
8. “FDA Reverses Stance to Confirm NMN Is Lawful for Use in Dietary Supplements.” Nutraceuticalbusinessreview.com, 2025, nutraceuticalbusinessreview.com/fda-reverses-stance-to-confirm-nmn-is-lawful.